The hilarity begins when professor Sherman Klump finds romance with fellow DNA specialist, Denise Gaines, and discovers a brilliant formula that reverses aging. But Sherman's thin and obnoxious alter ego, Buddy Love, wants out...and a big piece of the action. And when Buddy gets loose, things get seriously nutty.
Eddie Murphy
as Sherman Klump / Buddy Love / Granny Klump / Mama Klump / Papa Klump / Young Papa Klump / Ernie Klump / Lance Perkins
Janet Jackson
as Denise
Larry Miller
as Dean Richmond
John Ales
as Jason
Richard Gant
as Denise's Father
Anna Maria Horsford
as Denise's Mother
Melinda McGraw
as Leanne Guilford
Jamal Mixon
as Ernie Klump, Jr.
Gabriel Williams
as Issac
Chris Elliott
as Restaurant Manager
Duffy Taylor
as Restaurant Trainee
Earl Boen
as Dr. Knoll
