A cliché hunchbacked evil scientist's assistant aspires to become a scientist himself, much to the displeasure of the rest of the evil science community.
John Cusack
as Igor (voice)
Myleene Klass
as Dr. Holzwurm (voice)
Robin Walsh
as Dr. Holzwurm's Igor (voice)
Matt McKenna
as Dr. Herzschlag (voice)
John Cleese
as Dr. Glickenstein (voice)
Steve Buscemi
as Scamper (voice)
Sean Hayes
as Brain (voice)
Eddie Izzard
as Dr. Schadenfreude (voice)
Jay Leno
as King Malbert (voice)
Jennifer Coolidge
as Jaclyn / Heidi (voice)
Molly Shannon
as Eva (voice)
James Lipton
as Himself
