A pampered Beverly Hills chihuahua named Chloe who, while on vacation in Mexico with her owner Viv's niece, Rachel, gets lost and must rely on her friends to help her get back home before she is caught by a dognapper who wants to ransom her.
Drew Barrymore
as Chloe (voice)
Piper Perabo
as Rachel Ashe Lynn
Andy García
as Delgado (voice)
George Lopez
as Papi (voice)
Paul Rodríguez
as Chico (voice)
Plácido Domingo
as Monte (voice)
Edward James Olmos
as Diablo (voice)
Loretta Devine
as Delta (voice)
Jamie Lee Curtis
as Aunt Viv
Luis Guzmán
as Chucho (voice)
Eddie 'Piolin' Sotelo
as Rafa (voice)
Carlos Juvera
as Tomás (voice)
