Bio-technologist Govind K Somaiyya sets about on a precarious journey to India to retrieve a vial containing a deadly virus and prevent it from reaching the wrong hands of an ex-CIA agent and deadly assassins.
Kamal Haasan
as Govindarajan Ramaswamy / Rangaraja Nambi / George W. Bush / Avtaar Singh / Balram Naidu / Christian Fletcher / Shinghen Narahasi / Krishnaveni / Vincent Poovaragavan / Kalifullah Mukhtaar
Asin Thottumkal
as Kodhai Radha / Andal
Mallika Sherawat
as Jasmine
Jaya Prada
as Ranjitha Singh
Napoleon
as Kulothunga Chola II
P. Vasu
as J. Ragavendra (Jaa Raa)
Raghuram
as Appa Rao
Chakri Toleti
as Sairam
Shammu
as Assistant Biotechnologist
M. S. Bhaskar
as Broadway Kumar
Vaiyapuri
as Prabhu
Chitti Babu
as Ekambaram
