After a car crash sends repressed cartoonist Stu into a coma, he and the mischievous Monkeybone, his hilarious alter-ego, wake up in a wacked-out waystation for lost souls. When Monkeybone takes over Stu's body and escapes to wreak havoc on the real world, Stu has to find a way to stop him before his sister pulls the plug on reality forever!
Brendan Fraser
as Stu Miley
Bridget Fonda
as Dr. Julie McElroy
John Turturro
as Monkeybone (voice)
Chris Kattan
as Organ Donor Stu
Giancarlo Esposito
as Hypnos
Rose McGowan
as Miss Kitty
Dave Foley
as Herb
Megan Mullally
as Kimmy Miley
Bob Odenkirk
as Head Surgeon
Whoopi Goldberg
as Death
Pat Kilbane
as Burger God Representative
Lisa Zane
as Medusa
