Sherlock Holmes investigates a series of so-called "pajama suicides". He knows the female villain behind them is as cunning as Moriarty and as venomous as a spider. Based on "The Sign of Four" and the short stories "The Dying Detective", "The Final Problem", "The Speckled Band" and "The Adventure of the Devil's Foot".
Basil Rathbone
as Sherlock Holmes
Nigel Bruce
as Dr. John H. Watson
Gale Sondergaard
as Adrea Spedding
Dennis Hoey
as Insp. Lestrade
Vernon Downing
as Norman Locke
Alec Craig
as Radlik
Arthur Hohl
as Adam Gilflower
Mary Gordon
as Mrs. Hudson
Teddy Infuhr
as Larry (uncredited)
Donald Stuart
as Artie - Shooting Gallery Attendant (uncredited)
Harry Cording
as Fred Garvin (uncredited)
Belle Mitchell
as Fortune Teller (uncredited)
