Test pilot Tuck Pendleton volunteers to test a special vessel for a miniaturization experiment. Accidentally injected into a neurotic hypochondriac, Jack Putter, Tuck must convince Jack to find his ex-girlfriend, Lydia Maxwell, to help him extract Tuck and his ship and re-enlarge them before his oxygen runs out.
Dennis Quaid
as Lt. Tuck Pendleton
Martin Short
as Jack Putter
Meg Ryan
as Lydia Maxwell
Kevin McCarthy
as Victor Eugene Scrimshaw
Fiona Lewis
as Dr. Margaret Canker
Vernon Wells
as Mr. Igoe
Robert Picardo
as The Cowboy
Dick Miller
as Cab Driver
Wendy Schaal
as Wendy
Harold Sylvester
as Pete Blanchard
William Schallert
as Dr. Greenbush
Henry Gibson
as Mr. Wormwood
