Bianca's universe turns upside down when she learns that her high school refers to her as a ‘DUFF' (Designated Ugly Fat Friend). Hoping to erase that label, she enlists the help of a charming jock and her favorite teacher. Together they'll face the school's mean girl and remind everyone that we are all someone's DUFF… and that's totally fine.
Mae Whitman
as Bianca Piper
Robbie Amell
as Wesley Rush
Bella Thorne
as Madison Morgan
Skyler Samuels
as Jess Harris
Bianca A. Santos
as Casey Cordero
Romany Malco
as Principal Buchanon
Ken Jeong
as Mr. Arthur
Chris Wylde
as Mr. Fillmore
Allison Janney
as Dottie Piper
Seth Meriwether
as A.J.
Rebecca Weil
as Caitlyn
Brian Dewar McNamara
as Matt
