Intertwining couples and singles in Los Angeles break-up and make-up based on the pressures and expectations of Valentine's Day.
Bradley Cooper
as Holden Wilson
Jessica Alba
as Morley Clarkson
Kathy Bates
as Susan Milton
Jessica Biel
as Kara Monahan
Eric Dane
as Sean Jackson
Patrick Dempsey
as Dr. Harrison Copeland
Héctor Elizondo
as Edgar Paddington
Jamie Foxx
as Kelvin Moore
Jennifer Garner
as Julia Fitzpatrick
Topher Grace
as Jason Morris
Anne Hathaway
as Liz Curran
Carter Jenkins
as Alex Franklin
