A mysterious creature destroys 70% of the moon. The creature then warns that if he is not destroyed by March of next year, Earth will be next. The creature also demands that he becomes the homeroom teacher for 3rd grade E class at Kunugigaoka Junior High School. The government is powerless to say no. The creature then becomes the homeroom teacher of 3rd grade E class which consists of failed students including Nagisa Shiota. The creature is called Teacher Koro. Meanwhile, the government requests that the students try to kill Teacher Koro even though he possesses super powers. The government offers a 10 billion yen reward for whomever successfully kills him. The students are confused by the situation, but decide to kill Teacher Koro. When their class begins with Teacher Koro, the students finds themselves having a good time with their new teacher.
二宮和也
as Koro Sensei (voice)
山田涼介
as Nagisa Shiota
菅田将暉
as Karuma Akabane
山本舞香
as Kaede Kayano
竹富聖花
as Rio Nakamura
優希美青
as Yukiko Kanzaki
上原実矩
as Manami Okuda
椎名桔平
as Tadaomi Karasuma
Kouki Osamura
as Taiga Okajima
Takumi Ooka
as Ryunosuke Chiba
Saki Takahashi
as Hinata Okano
Yuuhi Kato
as Yuuma Isogai
