For years, Blade has fought against the vampires in the cover of the night. But now, after falling into the crosshairs of the FBI, he is forced out into the daylight, where he is driven to join forces with a clan of human vampire hunters he never knew existed—The Nightstalkers. Together with Abigail and Hannibal, two deftly trained Nightstalkers, Blade follows a trail of blood to the ancient creature that is also hunting him—the original vampire, Dracula.
Wesley Snipes
as Eric Brooks / Blade
Jessica Biel
as Abigail Whistler
Ryan Reynolds
as Hannibal King
Kris Kristofferson
as Abraham Whistler
Dominic Purcell
as Dracula / Drake
Parker Posey
as Danica Talos
Natasha Lyonne
as Sommerfield
James Remar
as Ray Cumberland
John Michael Higgins
as Dr. Edgar Vance
Patton Oswalt
as Hedges
Callum Keith Rennie
as Asher Talos
Paul Lévesque
as Jarko Grimwood
