After the disappearance of her scientist father, three peculiar beings send Meg, her brother, and her friend to space in order to find him.
Storm Reid
as Meg Murry
Oprah Winfrey
as Mrs. Which
Reese Witherspoon
as Mrs. Whatsit
Mindy Kaling
as Mrs. Who
Levi Miller
as Calvin O'Keefe
Deric McCabe
as Charles Wallace Murry
Chris Pine
as Dr. Alex Murry
Gugu Mbatha-Raw
as Dr. Kate Murry
Zach Galifianakis
as The Happy Medium
Rowan Blanchard
as Veronica Kiley
Michael Peña
as Red
André Holland
as Principal Jenkins
