Detective Sherlock Holmes and Dr. John Watson join forces to investigate a mysterious murder at Buckingham Palace. It seems like an open-and-shut case as all signs point to Professor James Moriarty, the criminal mastermind and longtime nemesis of the crime-solving duo. When new twists and clues begin to emerge, the world's greatest sleuth and his trusted assistant must now use their legendary wits and ingenious methods to catch the killer as they only have four days before the queen becomes the next victim.
Will Ferrell
as Sherlock Holmes
John C. Reilly
as Dr. John Watson
Rebecca Hall
as Dr. Grace Hart
Kelly Macdonald
as Mrs. Martha Hudson
Rob Brydon
as Inspector Lestrade
Lauren Lapkus
as Millie
Pam Ferris
as Queen Victoria
Ralph Fiennes
as Prof. James Moriarty / Jacob Musgrave
Adam Scherr
as Brawn
Kieran O'Brien
as PC Smalls
Noah Jupe
as Doxy
Bella Ramsey
as Flotsam
