Former radio singer Kay learns from her gossipy friends that her husband, Steve, has had an affair with chorus girl Crystal. Devastated, Kay tries to ignore the information, but when Crystal performs one of her musical numbers at a charity benefit, she breaks down and goes to Reno to file for divorce. However, when she hears that gold-digging Crystal is making Steve unhappy, Kay resolves to get her husband back. The Opposite Sex is a remake of the 1939 comedy The Women.
June Allyson
as Kay Ashley Hilliard
Joan Collins
as Crystal Allen
Dolores Gray
as Sylvia Fowler
Ann Sheridan
as Amanda Penrose
Ann Miller
as Gloria Dahl
Leslie Nielsen
as Steve Hilliard
Jeff Richards
as Buck Winston
Agnes Moorehead
as Countess Lavaliere
Charlotte Greenwood
as Lucy
Joan Blondell
as Edith Potter
Sam Levene
as Mike Pearl
Bill Goodwin
as Howard Fowler
