Maggie is an alluring free spirit who won't let anyone – or anything – tie her down. But she meets her match in Jamie, whose relentless and nearly infallible charm serves him well with the ladies and the cutthroat world of pharmaceutical sales. Maggie and Jamie's evolving relationship takes them both by surprise, as they find themselves under the influence of the ultimate drug: love.
Jake Gyllenhaal
as Jamie Randall
Anne Hathaway
as Maggie Murdock
Oliver Platt
as Bruce Winston
Hank Azaria
as Dr. Stan Knight
Josh Gad
as Josh Randall
Gabriel Macht
as Trey Hannigan
Judy Greer
as Cindy
Jill Clayburgh
as Nancy Randall
George Segal
as Dr. James Randall
Kate Jennings Grant
as Gina
Katheryn Winnick
as "Lisa"
Kimberly Scott
as Gail
