Dr. Lily Houghton enlists the aid of wisecracking skipper Frank Wolff to take her down the Amazon in his dilapidated boat. Together, they search for an ancient tree that holds the power to heal – a discovery that will change the future of medicine.
Dwayne Johnson
as Frank Wolff
Emily Blunt
as Dr. Lily Houghton
Edgar Ramírez
as Lope de Aguirre
Jack Whitehall
as McGregor Houghton
Jesse Plemons
as Prince Joachim
Paul Giamatti
as Nilo
Veronica Falcón
as Trader Sam
Dani Rovira
as Sancho
Quim Gutiérrez
as Melchor
Dan Dargan Carter
as Gonzalo
Andy Nyman
as Sir James Hobbs-Coddington
Raphael Alejandro
as Zaqueu
