Makunouchi Ippo is the new Featherweight champion of Japan and is now ready for his first title defense. His opponent, the former Jr. Featherweight champion and a medical student, Sanada Kazuki. In addition to this feud, Sanada is being coached by Kamogawa's former rival, Hama Dankichi. What makes things worse is that Sanada works at the same hospital where Kumi is a nurse at and everybody at the hospital wants Sanada to win. Not only does Ippo have to defend his title, he has to reclaim his love.
喜安浩平
as Ippo Makunouchi (voice)
小山力也
as Mamoru Takamura (voice)
内海賢二
as Genji Kamogawa (voice)
小野坂昌也
as Takeshi Sendo (voice)
関智一
as Ichirou Miyata (voice)
高木渉
as Masaru Aoki (voice)
Masahiro Tanaka
as Ryo Mashiba (voice)
藤原啓治
as Tatsuya Kimura (voice)
