Peter Parker is going through a major identity crisis. Burned out from being Spider-Man, he decides to shelve his superhero alter ego, which leaves the city suffering in the wake of carnage left by the evil Doc Ock. In the meantime, Parker still can't act on his feelings for Mary Jane Watson, a girl he's loved since childhood. A certain anger begins to brew in his best friend Harry Osborn as well...
Tobey Maguire
as Spider-Man / Peter Parker
Kirsten Dunst
as Mary Jane Watson
James Franco
as Harry Osborn
Alfred Molina
as Doc Ock / Otto Octavius
Rosemary Harris
as May Parker
J.K. Simmons
as J. Jonah Jameson
Donna Murphy
as Rosalie Octavius
Daniel Gillies
as John Jameson
Dylan Baker
as Dr. Curt Connors
Bill Nunn
as Joseph 'Robbie' Robertson
Vanessa Ferlito
as Louise
Aasif Mandvi
as Mr. Aziz
