The Stratton kids, Samantha and Chip, and their grandmother, Ada, drive to visit their Uncle Stuart. Grandma collapses and dies in a strange town, leaving the kids and Lassie on their own.
Sally Boyden
as Samantha Stratton
Shane Sinutko
as Chip Stratton
John Reilly
as Stuart
David Wayne
as Amos
Gene Evans
as Sheriff Marsh
Lee Bryant
as Kathy
Jeff Harlan
as Buzz
Jeanette Nolan
as Ada Stratton
John McIntire
as Dr. Spreckles
Jim Antonio
as Mr. Waldrup
Logan Ramsey
as Flannagan
Lucille Benson
as Juno
