Leonard Shelby is tracking down the man who raped and murdered his wife. The difficulty of locating his wife's killer, however, is compounded by the fact that he suffers from a rare, untreatable form of short-term memory loss. Although he can recall details of life before his accident, Leonard cannot remember what happened fifteen minutes ago, where he's going, or why.
Guy Pearce
as Leonard
Carrie-Anne Moss
as Natalie
Joe Pantoliano
as Teddy
Mark Boone Junior
as Burt
Russ Fega
as Waiter
Jorja Fox
as Leonard's Wife
Stephen Tobolowsky
as Sammy
Harriet Sansom Harris
as Mrs. Jankis
Thomas Lennon
as Doctor
Callum Keith Rennie
as Dodd
Kimberly Campbell
as Blonde
Marianne Muellerleile
as Tattooist
