A nationwide manhunt for Hank Venture leads to untold dangers and unexpected revelations, while The Monarch is literally out for Dr Venture's blood. An imposing evil from the past reemerges to wreak havoc on the Ventures, The Guild, and even the Monarch marriage—it will take friends and foes alike to restore the Ventures' world to order… or end it once and for all.
James Urbaniak
as Dr. Venture / Phantom Limb / Jonas Venture Jr. (voice)
Patrick Warburton
as Brock Samson (voice)
Michael Sinterniklaas
as Dean Venture (voice)
Doc Hammer
as Dr. Mrs. The Monarch / Henchman 21 / Shoreleave / Billy Quizboy / Dermott / Red Mantle / Rose / Ward (voice)
Christopher McCulloch
as Hank Venture / The Monarch / Sgt. Hatred / Hunter Gathers / Pete White / Watch (voice)
Nina Arianda
as Mantilla (voice)
Clancy Brown
as Red Death / Daisy (voice)
John Hodgman
as Snoopy (voice)
Hal Lublin
as Clayton / Seth / Tour Guide (voice)
Jane Lynch
as Bobbi St. Simone (voice)
Charles Parnell
as Jefferson Twilight / OSI Agent (voice)
Jay Pharoah
as Nuno Blood / Additional Blackulas (voice)
