Virginia, 1803. After the United States of America acquires the inmense Louisiana territory from France, a great expedition, led by William Lewis and Meriwether Clark, is sent to survey the new lands and go where no white man has gone before.
Fred MacMurray
as Cpt. Meriwether Lewis
Charlton Heston
as Lt. William Clark
Donna Reed
as Sacajawea
Barbara Hale
as Julia Hancock
William Demarest
as Sgt. Gass
Alan Reed
as Charbonneau
Eduardo Noriega
as Chief Cameahwait
Larry Pennell
as Wild Eagle
Herbert Heyes
as President Thomas Jefferson
Lester Matthews
as Mr. Hancock
Argentina Brunetti
as Shoshone Woman (uncredited)
Julia Montoya
as Crow Woman (uncredited)
