Jimmy is enlisted as a spy by the Big Top Secret Organization. His mission: find and rescue Agent X - who turns out to be Jimmy's movie hero, Jet Fusion.
Debi Derryberry
as James Isaac 'Jimmy' Neutron (voice)
Christian Slater
as Jet Fusion (voice)
Wendie Malick
as Beautiful Gorgeous (voice)
Michael Clarke Duncan
as Commander Baker (voice)
Tim Curry
as Professor Calamitous (voice)
Dan Castellaneta
as Professor Crank (voice)
Frank Welker
as Goddard (voice)
Rob Paulsen
as Carl Wheezer / Monk / Voice / Clam (voice)
Megan Cavanagh
as Judy Neutron / Ms. Jingle Bells / Female Monk (voice)
Mark DeCarlo
as Hugh Neutron (voice)
Jeffrey Garcia
as Sheen Estevez (voice)
Andrea Martin
as Ms. Fowl (voice)
