Jimmy is a young man who was born without an immune system and has lived his life within a plastic bubble in his bedroom... who pines for the sweet caresses of girl-next-door Chloe. But when Chloe decides to marry her high school boyfriend, Jimmy – bubble suit and all – treks cross-country to stop her.
Jake Gyllenhaal
as Jimmy Livingston
Swoosie Kurtz
as Mrs. Livingston
Marley Shelton
as Chloe
Danny Trejo
as Slim
John Carroll Lynch
as Mr. Livingston
Verne Troyer
as Dr. Phreak
Dave Sheridan
as Mark
Brian George
as Pushpop
Patrick Cranshaw
as Pappy / Pippy
Stephen Spinella
as Chicken Man
Ever Carradine
as Lisa, Mark's Sister
Geoffrey Arend
as Flipper Boy
